BICD2 promotes ciliogenesis by facilitating CP110 removal from the mother centriole
Bibliographic record
Abstract
Cilia are hair-like organelles that protrude from the cell surface and play vital roles in embryonic development and tissue homeostasis. Removal of centriolar coiled-coil protein 110 (CP110) from the mother centriole is a critical step in ciliogenesis, yet the underlying mechanism remains largely unknown. In this study, we identify bicaudal D cargo adaptor 2 (BICD2) as a mother centriole protein that directly binds CP110 and facilitates its removal to promote ciliogenesis. Depletion of BICD2 significantly inhibits ciliogenesis and the removal of CP110, whereas knockdown of CP110 rescues ciliogenesis defects in BICD2-deficient cells. Additionally, we show that BICD2 is recruited to the mother centriole during ciliogenesis, where it directly binds and removes CP110. Moreover, zebrafish bicd2 morphants exhibit developmental abnormalities and defective ciliogenesis, which can be reversed by reintroducing bicd2 mRNA or depleting Cp110. Our findings establish BICD2 as a key regulator of ciliogenesis through its role in CP110 removal, shedding light on the molecular mechanisms of cilia formation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".