Abstract FR577: Pregnancy-Induced Hypertension and Offspring Cardiovascular Risk: A Systematic Review of Long-Term Outcomes
Bibliographic record
Abstract
Introduction: Gestational hypertension and preeclampsia in pregnancy may cause the child to have a greater risk for heart disease later in life. Epidemiological studies have shown that children originating from hypertensive pregnancies are more likely to have higher blood pressure (BP) and risk factors as they grow up. To understand these connections, we reviewed the published studies covering long-term heart problems in the children from hypertension pregnancies Hypertension: Hypertension in mothers during pregnancy changes genes in the offspring's cardiovascular system, causing arteries to harden more and blood pressure to increase over time, beginning in childhood and through adulthood. Methods: We used the PRISMA methods to look for cohort and case-control studies studying cardiovascular risk markers or events in children and adults of mothers with hypertension during pregnancy. Two of the fourteen articles were observational, with the rest being observational studies. We obtained offspring BP reading, hypertension rate , metabolic results, and early signs of cardiovascular disease (e.g., arterial thickness or heart functioning). We measured the quality of each study using the Newcastle-Ottawa Scale. Results: Offspring from hypertensive pregnancies had higher blood pressure from childhood than those born during normal BP pregnancies. Analyses suggested that by young adulthood, people born to hypertensive mothers had slightly higher average systolic BP and were more susceptible to hypertension. Studies showed that these offspring had increased body mass indexes and more aspects of metabolic syndrome. Clear forerunners of cardiovascular disease also emerged: for instance, adolescents who experienced preeclampsia showed higher carotid intima-media thickness and lower arterial elasticity. Even after looking at genetic and lifestyle variables, studies still observed an association between when the mother had hypertension and her children's outcomes. The evidence looked average, as some possible influences were not controlled. Conclusions: The review indicates that exposure to maternal hypertension in utero is associated with higher blood pressure and elevated cardiovascular risk in offspring later in life. These findings underscore the importance of early cardiovascular risk assessment and preventive interventions for individuals born from hypertensive pregnancies, highlighting maternal health as a determinant of long-term offspring outcomes.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.031 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.009 | 0.008 |
| Bibliometrics | 0.010 | 0.012 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".