Chronic psychological stress during adolescence induces altered postpartum behaviours and intergenerational effects in mice
Bibliographic record
Abstract
Human studies of postpartum depression describe pre-pubertal adolescent stress as a predisposing factor of the condition, but varying degrees and types of stress that individuals may experience across childhood and adolescence make it difficult to describe the role of specific contributing factors. Animal models allow for standardization of experienced stress, but the effects of developmental stress and subsequent postpartum behaviours have not been well studied in rodent models. To address this gap in the literature, we subjected mice to chronic psychological stress in the early adolescent period using a chronic predator stress paradigm (aCPS). Control and aCPS mice were later bred to study the effects of aCPS on maternal postpartum behaviour. We found that aCPS dams provided less maternal care to their pups, groomed less frequently in the sucrose splash test, and consumed less of a high effort food source (unshelled sunflower seeds) in a food foraging test after giving birth compared to controls. The offspring of aCPS mice (ancestral aCPS) show some increased anxiety-like behaviours as adults, suggesting an intergenerational effect. Our findings suggest that early adolescent predator stress impacts aspects of motivation in the postpartum period and has intergenerational effects that persist into adulthood in both males and females.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.002 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".