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Record W4415293464 · doi:10.1101/2025.10.16.682912

State dependent shifts in large scale functional topographies

2025· preprint· en· W4415293464 on OpenAlexafffund
Yezhou Wang, Jordan DeKraker, Raúl Rodríguez‐Cruces, Donna Gift Cabalo, Jessica Royer, Alexander Ngo, Brontë Mckeown, Youngeun Hwang, Ilana R. Leppert, Tamara Vanderwal, Nathan Spreng, Sofie L. Valk, Jonathan Smallwood, Alan C. Evans, Boris C. Bernhardt

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldComputer Science
TopicTopological and Geometric Data Analysis
Canadian institutionsUniversity of British ColumbiaMontreal Neurological Institute and Hospital
FundersFonds de recherche du Québec – Nature et technologiesCanadian Institutes of Health ResearchHospital for Sick ChildrenNatural Sciences and Engineering Research Council of CanadaCanada Research Chairs
KeywordsDefault mode networkHuman Connectome ProjectFunctional connectivityResting state fMRIConnectomeCognitionNeuroimagingSensory systemFunctional magnetic resonance imagingMagnetoencephalography

Abstract

fetched live from OpenAlex

Abstract Although functional networks can be consistently identified across cognitive states, they also undergo dynamic reconfigurations across different contexts. For example, naturalistic movie watching paradigms amplify activity in sensory systems compared to resting conditions. However, it remains unclear how these different states affect large-scale brain organization. The current study leveraged high-resolution in vivo 7T fMRI data from the Human Connectome Project (HCP) and the Precision NeuroImaging (PNI) datasets to examine large scale functional connectivity changes between resting and movie-watching conditions. To understand these changes within topographic and geometric principles of brain organization, connectivity shifts were stratified relative to macroscale cortical hierarchy and geodesic distance. Our results revealed that primary sensory areas showed increased local connectivity and reduced long-range interactions during movie watching relative to resting conditions, whereas the default mode network (DMN) exhibited an opposing pattern characterized by reduced within-network long-range connectivity and enhanced connectivity with distant regions outside the DMN. Together, these findings demonstrate that different cognitive states involve geometry-and hierarchy-informed reorganization of large-scale functional networks.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.217
Teacher spread0.204 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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