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Record W4415294606 · doi:10.1038/s41598-025-20297-y

Executive functions predict time reference processing in French-speaking people with Alzheimer’s disease

2025· article· en· W4415294606 on OpenAlexaff
Évodie Schaffner, Mélanie Sandoz, Noémie Auclair‐Ouellet, Jean‐François Démonet, Marion Fossard

Bibliographic record

VenueScientific Reports · 2025
Typearticle
Languageen
FieldNeuroscience
TopicNeurobiology of Language and Bilingualism
Canadian institutionsMcGill University
FundersCentre Hospitalier Universitaire VaudoisSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungNational Science Foundation
KeywordsCognitionExecutive functionsCognitive flexibilityDiseaseWorking memoryVerbFlexibility (engineering)Control (management)

Abstract

fetched live from OpenAlex

The ability to express time through language, known as time reference, is impaired in people with Alzheimer's disease. While cognitive impairments have been documented in this population, particularly in executive functions, few studies have examined how these deficits impact time reference abilities, including tense and grammatical aspect. Since producing time reference requires the integration of grammatical, conceptual, and subjective information, potentially demanding in processing resources, the aim of this study was to investigate whether the cognitive profile (i.e., executive function abilities) of French-speaking people with biologically probable Alzheimer's disease determines their ability in time reference. Verb inflection tasks and cognitive tests were administered to 21 people with a diagnosis of Alzheimer's disease confirmed by cerebrospinal fluid or amyloid positron emission tomography (PET) biomarkers and a control group. Results revealed that individuals with Alzheimer's disease have difficulty with tense and aspect marking, with verbal working memory, inhibition, and mental flexibility playing a significant role in time reference processing. These findings suggest that deficits in executive functions impact the ability of French speakers with Alzheimer's disease to mark tense and grammatical aspect, highlighting the cognitive basis of time reference impairments in this population.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.022
Threshold uncertainty score0.045

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.277
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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