RAISE: A self-driving laboratory for interfacial property formulation discovery
Bibliographic record
Abstract
Surface wettability is a critical design parameter for biomedical devices, coatings, and textiles. Contact angle measurements quantify liquid-surface interactions, which depend strongly on liquid formulation. Herein, we present the Robotic Autonomous Imaging Surface Evaluator (RAISE), a closed-loop, self-driving laboratory that is capable of linking liquid formulation optimization with surface wettability assessment. RAISE comprises a full experimental orchestrator with the ability of mixing liquid ingredients to create varying formulation cocktails, transferring droplets of prepared formulations to a high-throughput stage, and using a pick-and-place camera tool for automated droplet image capture. The system also includes an automated image processing pipeline to measure contact angles. This closed loop experiment orchestrator is integrated with a Bayesian Optimization (BO) client, which enables iterative exploration of new formulations based on previous contact angle measurements to meet user-defined objectives. The system operates in a high-throughput manner and can achieve a measurement rate of approximately 1 contact angle measurement per minute. Here we demonstrate RAISE can be used to explore surfactant wettability and how surfactant combinations create tunable formulations that compensate for purity-related variations. Furthermore, multi-objective BO demonstrates how precise and optimal formulations can be reached based on application-specific goals. The optimization is guided by a desirability score, which prioritizes formulations that are within target contact angle ranges, minimize surfactant usage and reduce cost. This work demonstrates the capabilities of RAISE to autonomously link liquid formulations to contact angle measurements in a closed-loop system, using multi-objective BO to efficiently identify optimal formulations aligned with researcher-defined criteria.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.003 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.007 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".