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Record W4415349418 · doi:10.1161/strokeaha.125.050752

Applying Neuroeconomic Principles to Stroke Care: Bridging Evidence to Practice

2025· review· en· W4415349418 on OpenAlexaff
Gustavo Saposnik, Yongchai Nilanont, S. Claiborne Johnston

Bibliographic record

VenueStroke · 2025
Typereview
Languageen
FieldMedicine
TopicAcute Ischemic Stroke Management
Canadian institutionsEmergent BioSolutions (Canada)University of Toronto
Fundersnot available
KeywordsBridging (networking)WorkflowRehabilitationPsychological interventionAcknowledgementFraming (construction)Choice architectureBehavioral economics

Abstract

fetched live from OpenAlex

Over the past 10 years, stroke care has seen remarkable technological and pharmacological breakthroughs-ranging from advanced thrombectomy devices and streamlined thrombolytic therapies like tenecteplase to artificial intelligence-powered imaging and rehabilitation tools. Yet adoptions remain uneven due to fragmented systems, low adherence, and inconsistent implementation. To overcome these barriers, neuroeconomics-a multifaceted integration of neuroscience, behavioral economics, psychology, and clinical medicine-sharpens decision-making under uncertainty and drives sustained behavior change. Behavioral economics offers a toolkit of low-cost, scalable interventions-nudges, default options, framing effects, commitment devices, incentives, gamification, and social-norm feedback-that can be woven into every phase of stroke management. Embedding preselected treatment orders in electronic health records, default-scheduling follow-up appointments, and delivering tailored digital reminders have all boosted adherence to medications, rehabilitation exercises, and preventive measures. Financial rewards and community-based feedback loops have improved both clinicians' prescribing habits and patient self-management. Early pilot programs demonstrate that even small tweaks in workflow or choice architecture can yield outsized improvements in timely reperfusion, secondary prevention uptake, and long-term outcomes. By embedding evidence-based interventions directly into care decisions, the integration of neuroeconomic principles helps bridge the gap between scientific innovation and its transformative impact on patient outcomes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.027
metaresearch head score (Gemma)0.089
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.027
Threshold uncertainty score0.143

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0270.089
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0050.002
Bibliometrics0.0060.006
Science and technology studies0.0010.003
Scholarly communication0.0060.006
Open science0.0030.004
Research integrity0.0040.005
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.060
GPT teacher head0.371
Teacher spread0.311 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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