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Record W4415383356 · doi:10.56367/oag-048-12295

Connecting Canada for rare disease care and research

2025· article· en· W4415383356 on OpenAlexaffabout
François P. Bernier, Kym M. Boycott, Leanne M. Ward, Ian Stedman, Durhane Wong‐Rieger, Svenja Espenhahn

Bibliographic record

VenueOpen Access Government · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Rare Diseases
Canadian institutionsYork UniversityUniversity of OttawaCanadian Respiratory Research NetworkCanadian Organization for Rare DisordersUniversity of Calgary
Fundersnot available
KeywordsRare diseaseDiseaseHealth careRare eventsPublic healthPatient care

Abstract

fetched live from OpenAlex

Connecting Canada for rare disease care and research The Canadian Rare Disease Network (CRDN) is uniting care, research, and lived experience to improve the rare disease journey in Canada. Over 3 million people across Canada are affected by 7,000+ known rare diseases (RDs), many of which are severe, progressive, and life-limiting [1, 2]. These numbers reflect real people: children spending their early years in hospitals, parents turned full-time caregivers and advocates, and adults facing daily uncertainty about their health and future. Yet patients continue to fall through cracks of Canada’s health and research systems because they don’t fit the mold.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.016
metaresearch head score (Gemma)0.059
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.917
Threshold uncertainty score0.601

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0160.059
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0070.005
Science and technology studies0.0090.004
Scholarly communication0.0100.004
Open science0.0040.012
Research integrity0.0070.007
Insufficient payload (model declined to judge)0.1400.022

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.396
Teacher spread0.363 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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