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Record W4415422865 · doi:10.1016/j.lana.2025.101278

Call to action: integrating steatotic liver disease into public health strategies in Canada

2025· review· en· W4415422865 on OpenAlexafffundabout
Sahar Saeed, Jessica Burnside, Cindy Wen, Keyur Patel, Alnoor Ramji, Mark G. Swain, Giada Sebastiani

Bibliographic record

VenueThe Lancet Regional Health - Americas · 2025
Typereview
Languageen
FieldMedicine
TopicLiver Disease Diagnosis and Treatment
Canadian institutionsMcGill University Health CentreUniversity of CalgaryUniversity of British ColumbiaUniversity Health NetworkQueen's University
FundersCanadian Institutes of Health ResearchAbbVieFonds de Recherche du Québec - SantéGilead Sciences
KeywordsPublic healthEpidemiologyPreparednessObesityCirrhosisDiseaseFatty liverLiver disease

Abstract

fetched live from OpenAlex

Steatotic liver disease (SLD), formerly known as fatty liver disease, is the most common chronic liver condition, affecting one in three people in the Americas, including Canada. Characterized by excess fat in the liver, SLD can progress from a benign state to advanced fibrosis and cirrhosis and is strongly linked to increased risks of cardiovascular disease, extra-hepatic cancers, and premature mortality. Despite its rising prevalence, SLD remains largely absent from Canada's public health agenda. With Canada's aging population, growing rates of obesity and type 2 diabetes, and ethnocultural diversity, the need for a coordinated public health response is urgent. We outline Canada's distinct SLD epidemiology and highlight critical gaps in surveillance, policy, clinical guidelines, screening, and public awareness. We also propose actionable strategies grounded in implementation science to guide the scale-up of effective interventions, thereby strengthening Canada's preparedness and mitigating long-term impacts.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.008
metaresearch head score (Gemma)0.014
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.944
Threshold uncertainty score0.404

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0080.014
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0030.005
Science and technology studies0.0020.002
Scholarly communication0.0050.002
Open science0.0030.003
Research integrity0.0040.006
Insufficient payload (model declined to judge)0.0070.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.231
GPT teacher head0.448
Teacher spread0.217 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes3
Has abstractyes

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Same venueThe Lancet Regional Health - AmericasSame topicLiver Disease Diagnosis and TreatmentFrench-language works237,207