SUN-227 HyperAldosteronism in Pregnancy Predicted Impacts (H.A.P.P.I. Project):A Prospective Cohort Study
Bibliographic record
Abstract
Abstract Disclosure: D. Oprea: None. A. Groleau: None. D. Laura: None. F. Lefrançois: None. M. Malick: None. A. Côté: None. M. Roy-Lacroix: None. M. Mahone: None. M. St-Jean: None. N. Sauvé: None. Background and Purpose: Primary aldosteronism (PA) is a frequent cause of secondary hypertension in young adults. However, to this day, there is still limited data regarding its prevalence and impact during pregnancy. Methods: The prospective phase of the H.A.P.P.I. project consisted of a bicentric cohort study, which was conducted between 2022 and 2024 in Quebec, Canada. All patients diagnosed with hypertensive disorders of pregnancy (HDP) who delivered in one of two university centers were eligible and were recruited during their post-partum follow-up to be screened for PA with an aldosterone/renin ratio (ARR). Additional confirmatory testing was performed if positive screening, according to local reference values. Patients with other endocrinopathies or secondary aldosteronism were excluded. Our primary objective was to determine PA prevalence among patients who experienced any subtype of HDP. Results: Among 240 included patients, 232 patients have completed their ARR screening. Preliminary results have shown positive screening in 18.1 % (n = 42) of patients, of which additional testing confirmed 18 (7.8%) PA diagnoses. Additional testing is pending for 24 patients. 44.4% (n = 8/18) of patients with confirmed PA were of African descent, as opposed to 10.0% in patients with negative PA screening (p < 0.001). Hypokalemia prevalence was not different between patients with positive PA screening and the ones with negative screening (antepartum: 14.3% (n = 3/21) vs. 13.0%, p = 1.00; post-partum: 7.1% (n = 2/28) vs. 8.3%, p = 1.00). 61.9% of patients with positive PA screening (n = 26/42) required labor induction because of HDP occurrence, compared to 49.5% of patients with negative PA screening (p = 0.173). Pre-eclampsia (54.8% (n = 23/42)) was the most frequent type of HDP in patients with positive PA screening, compared to chronic (19.1% (n = 8/42)) and gestational hypertension (40.5% (n = 17/42)). There was no difference between antepartum preeclampsia (72.9%, vs 75.6%, p = 1.00), postpartum preeclampsia (26.1%, vs. 24.4%, p = 1.00), and preeclampsia with adverse conditions (42.9%, vs. 41.6%, p = 1.00) compared to patients with negative ARR screening. Conclusion: So far, an estimated PA prevalence of 7.8% was described in patients recently diagnosed with HDP, who presented mainly as antepartum preeclampsia. Final results will be presented at the conference. Keywords: Primary Hyperaldosteronism, Aldosterone, Hypertension, Pregnancy-Induced, Pregnancy, Pregnant Women, Pregnancy Outcome. Presentation: Sunday, July 13, 2025
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".