SUN-252 Cardiovascular Disease In Adolescents and Young Women with Polycystic Ovary Syndrome: Atherogenic Dyslipidemia, Atherosclerotic Cardiovascular Disease and Cardiac Function
Bibliographic record
Abstract
Abstract Disclosure: D.F. Vine: None. X.F. Wu: None. M. Ghosh: None. M. Cree: None. H. Becher: None. P. Raggi: None. J. Windram: None. K. Nadeau: None. Background: Polycystic ovary syndrome (PCOS) is associated with increased cardiometabolic risk and cardiovascular disease (CVD). We have shown high-risk young adolescents and women with and without PCOS exhibit atherogenic dyslipidemia and atherosclerotic CVD (ACVD), and impaired cardiac function compared to healthy-weight controls. The aim of this study was to determine the natural history of cardiometabolic risk factors, carotid intimal medial thickness (cIMT) and cardiac function in young adolescents and women with and without PCOS. Methods: Datasets from the PCOS-Together (n=80, Canadian) and Androgens and Insulin Resistance Study (n=88, AIRS Children's Hospital Colorado, USA) were combined and harmonized for age-BMI matched (BMI >25 kg/m2) females aged 12-45 years with (PCOS) and without PCOS (non-PCOS control), and non-PCOS healthy-weight controls (BMI <25 kg/m2). Data included biochemical assessments (blood lipids, apoB, remnant-cholesterol, hormones, insulin, glucose). 2D/3D-echocardiography was performed and carotid intimal medial thickness (cIMT) and cardiac function indices collected. Data from PCOS and non-PCOS controls were compared to non-PCOS healthy-weight controls in age groups: 12-19, 20-29 and 30-45 yrs.Results: Free Testosterone, fasting triglycerides, remnant-cholesterol, apoB, non-HDL-C, LDL-C, insulin and HOMA-IR were increased in PCOS and non-PCOS controls, compared to healthy-weight controls at all age groups. FAI was highest and SHBG lowest in those with PCOS aged 12-19 yrs, compared to other age groups. cIMT, cardiac left ventricular (LV) mass and LV posterior wall thickness tended to be higher in PCOS and non-PCOS controls across all age groups, and increased by 10-20% at 30-45 yrs compared to healthy-weight controls. Cardiac E/A ratio was lower in PCOS and non-PCOS controls across all age groups, and declined in those with PCOS at 30-45 yrs. LV ejection fraction was lower in those with PCOS at 20-29 and 30-45 yrs, and LV global longitudinal strain was impaired in PCOS and non-PCOS controls at 30-45 yrs compared to healthy-weight controls. Conclusion: Our data shows the natural history of ACVD and impaired cardiac morphology and function in young women with and without PCOS, and these outcomes tend to be exacerbated in those with PCOS. Recommendations for early screening and detection, and studies to develop targeted interventions to mitigate CVD development in high-risk young women with and without PCOS are warranted. Presentation: Sunday, July 13, 2025
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.003 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".