Vine Tea Combined with a Lidocaine Microneedle Patch for Enhanced Treatment of Psoriasis
Bibliographic record
Abstract
Vine tea, a traditional Chinese herbal tea with well-known medicinal properties, contains various bioactive compounds, with dihydromyricetin (DMY) standing out as particularly notable. However, the therapeutic potential of DMY is hindered by its low solubility and limited ability to penetrate cell membranes. In this study, we present a novel approach utilizing a microneedle (MN) patch loaded with DMY in combination with lidocaine (LD), referred to as the DMY-LD MN patch, to effectively target thickened skin lesions in the treatment of psoriasis. The DMY-LD MN patch demonstrated the ability to penetrate the thickened epidermal layers associated with psoriasis, enabling sustained release of DMY and LD at the site of the skin lesion. In a murine model of psoriasis, both DMY and LD showed therapeutic efficacy when administered individually. Notably, the combined DMY and LD treatment regimen exhibited superior therapeutic outcomes. The DMY-LD MN patch offers a promising treatment strategy for psoriasis due to its durability, efficacy, cost-effectiveness, and safety.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".