"Varicella Zoster Virus and Cardiovascular Diseases: The Opinion of the Cardiologist"
Bibliographic record
Abstract
Varicella Zoster Virus (VZV) is a double-stranded DNA virus from the Herpesviridae family that affects humans only.The first clinical manifestation appears to be varicella, typical of childhood.After primary infection, however, VZV becomes latent in ganglion neurons along the entire neuroaxis.In the elderly and in immunocompromised individuals, the VZV reactivates and travels along the peripheral nerve fibers resulting in Zoster.However, it can also spread centrally and infect cerebral and extracranial arteries resulting in vasculopathy that can result in transient ischemic attacks, strokes, aneurysms, cavernous sinus thrombosis and giant cell arteritis, as well as granulomatous aortitis.The mechanisms of virusinduced pathological vascular remodeling are not fully understood; however, recent studies suggest that the inflammation and dysregulation of ligand-1 programmed death play a significant role.Few studies, on the other hand, evaluate the involvement of VZV in cardiovascular disease.This review therefore aims to analyze the link between VZV and cardiovascular disease, the efficacy of the vaccine as a protective mechanism and the target population of heart disease patients who could benefit from vaccination.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.005 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.005 | 0.008 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".