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Record W4415519238 · doi:10.1016/j.jtho.2025.09.070

OA12.02 CCTG IND227, a Randomized Trial of Chemotherapy + Pembrolizumab in Advanced Pleural Mesothelioma: Updated Analyses

2025· article· en· W4415519238 on OpenAlexaff
Scott A. Laurie, Quincy S. Chu, Francesco Perrone, L. Greillier, Wenjian Tu, M.C. Piccirillo, F. Grosso, G. Lo Russo, Marie Florescu, Manlio Mencoboni, Anna Morabito, Fabiana Letizia Cecere, Giovanni Luca Ceresoli, David E. Dawe, Paolo Andrea Zucali, Maria Pagano, John R. Goffin, María Luz Sánchez, C. Gridelli, G. Zalcman, Xavier Quantin, V. Westeel, P. Gargiulo, Sara Delfanti, D. Tu, Christopher W. Lee, N. Leighl, J. Sederias, Pamela Brown-Walker, Yan Luo, Sylvie Lantuéjoul, M.-S. Tsao, A. Scherpereel, P. Bradbury, Leonard W. Seymour

Bibliographic record

VenueJournal of Thoracic Oncology · 2025
Typearticle
Languageen
FieldMedicine
TopicOccupational and environmental lung diseases
Canadian institutionsPrincess Margaret Cancer CentreJuravinski Cancer CentreCancerCare ManitobaQueen's UniversitySpinal Cord Injury BCCentre Hospitalier de l’Université de Montréal
Fundersnot available
KeywordsPembrolizumabChemotherapyRandomized controlled trialMEDLINEStandard of care

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.024

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.005
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0040.005
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0020.002
Open science0.0010.000
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0070.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.449
Teacher spread0.427 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractno

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