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Record W4415522518 · doi:10.1080/24745332.2025.2451628

Unlocking small airways disease: The role of imaging biomarkers

2025· article· en· W4415522518 on OpenAlexaff
Miranda Kirby

Bibliographic record

VenueCanadian Journal of Respiratory Critical Care and Sleep Medicine · 2025
Typearticle
Languageen
FieldMedicine
TopicChronic Obstructive Pulmonary Disease (COPD) Research
Canadian institutionsToronto Metropolitan UniversitySt. Paul's Hospital
Fundersnot available
KeywordsMedical imagingSmall airwaysDiseaseComputed tomographyBiomarker

Abstract

fetched live from OpenAlex

This article highlights my research as a trainee with Dr. James C. Hogg, particularly on developing and investigating quantitative computed tomography (CT) imaging biomarkers of the small airways in chronic obstructive pulmonary disease (COPD). Together with Dr. Hogg, we developed a quantitative CT imaging measurement, termed the CT total airway count (TAC), using standard image acquisition and commercially available software. We showed that the CT TAC measure was significantly associated with lung function decline, reflects the reduction in terminal bronchioles in the same lung in COPD, and can be used to predict progression to COPD in current or former smokers with normal lung function. This work also fostered collaborations that extend investigation of quantitative CT airways to healthy aging and lung development research. Dr. Hogg’s legacy continues to inspire the development of novel imaging biomarkers for COPD risk and progression that may ultimately improve outcomes for individuals with COPD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.013
metaresearch head score (Gemma)0.024
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.013
Threshold uncertainty score0.071

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0130.024
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0030.001
Science and technology studies0.0010.006
Scholarly communication0.0070.011
Open science0.0010.003
Research integrity0.0040.011
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.297
Teacher spread0.281 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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