First-in-Human Experience With Septal Occluder for Dehiscence of Anterior Mitral Valve Leaflet Patch
Bibliographic record
Abstract
BACKGROUND: Mitral regurgitation secondary to infective endocarditis is often due to structural damage to the leaflets or apparatus, and the condition warrants surgical treatment. If surgery fails, percutaneous repair may be a viable option. CASE SUMMARY: We describe a case of anterior mitral valve leaflet perforation after infective endocarditis, initially treated by surgical patch repair, with subsequent dehiscence leading to recurrence of severe mitral regurgitation. After percutaneous closure with a septal occluder device, regurgitation was abolished. DISCUSSION: To our knowledge, this is the first case to demonstrate use of the Gore Cardioform septal occluder to treat postsurgical dehiscence of anterior mitral valve leaflet patch. Device selection needs to be decided on a case-by-case basis. TAKE-HOME MESSAGE: Percutaneous treatment of post-infective endocarditis anterior mitral valve leaflet perforation is feasible, even after failed surgical repair.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".