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Record W4415596710 · doi:10.1016/s0140-6736(25)02073-2

Percutaneous transcatheter valve replacement in individuals with mitral regurgitation unsuitable for surgery or transcatheter edge-to-edge repair: a prospective, multicountry, single-arm trial

2025· article· en· W4415596710 on OpenAlexaff
Mayra Guerrero, David Daniels, Raj Makkar, Vinod H. Thourani, Federico M. Asch, Michael Pham, Kamran I. Muhammad, Adam B. Greenbaum, Alejandro Arias Vásquez, J. Bradley Oldemeyer, Thom Dahle, Charanjit S. Rihal, Michael A. Morse, Evelio Rodríguez, Brian Patrick O’Neill, Mark J. Russo, Brian Whisenant, Pradeep Yadav, Dee Dee Wang, Moody Makar, David A. Baran, Paul G. Mahoney, Gautam Reddy, Philipp Blanke, John G. Webb, Curtiss Stinis, Matthew J. Price, Ignacio Inglessis‐Azuaje, Nathaniel B. Langer, Samir Kapadia, Bassem Chehab, Brett Grizell, Jason Foerst, Jorge Castellanos, Matthew J. Summers, Ricardo Yaryura, George L. Zorn, Peter Tadros, John Wang, Michael T. Mullen, Oluseun Alli, Daniel Pu, Santiago Garcia, Biswajit Kar, D. Murdoch, Frank Zidar, Faraz Kerendi, Hursh Naik, Josep Rodes-Cabau, Marvin H. Eng, Mohammad Ghani, Neil Fam, Nicolas M. Van Mieghem, Pranav Loyalka, Robert J. Cubeddu, Steven Burstein, Ali Gheissari, C.T. Klodell, Ilie Bard, Mark J. Ricciardi, M. Ng, Michael Young, Noah Jones, Mark Reisman, Somjot Brar, Vijay Iyer, Frank Van Der Kley, Mubashir Mumtaz, Ran Kornowski, Samer M Garas, Simon Redwood, Pinak Shah, Paul Sorajja, Neil Gheewala, Thomas Waggoner, David Lasorda

Bibliographic record

VenueThe Lancet · 2025
Typearticle
Languageen
FieldMedicine
TopicCardiac Valve Diseases and Treatments
Canadian institutionsSt. Paul's Hospital
FundersEdwards Lifesciences
KeywordsValve replacementPercutaneousMitral regurgitationMitral valve replacementRegurgitation (circulation)Mitral valve

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.003
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.328
Teacher spread0.295 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations21
Published2025
Admission routes1
Has abstractno

Explore more

Same venueThe Lancet→Same topicCardiac Valve Diseases and Treatments→French-language works237,207→