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Record W4415629202 · doi:10.1101/2025.10.27.684987

Fitness at the Expanding Front: An Exploration-Exploitation Trade-off in Phenotypic Switching

2025· preprint· W4415629202 on OpenAlexafffund
Hao Wang

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Language
FieldBiochemistry, Genetics and Molecular Biology
TopicEvolution and Genetic Dynamics
Canadian institutionsUniversity of Alberta
FundersNatural Sciences and Engineering Research Council of CanadaUniversity of Alberta
KeywordsForcing (mathematics)PopulationAdaptation (eye)LagSelection (genetic algorithm)Resilience (materials science)Cluster analysisEvolutionary dynamics

Abstract

fetched live from OpenAlex

Phenotypic switching is a key bet-hedging strategy for navigating the exploration-exploitation trade-off in fluctuating environments, yet its interplay with spatial population dynamics during range expansions remains poorly understood. We use an individual-based spatial simulation to investigate how switching strategies shape fitness (expansion speed) in heterogeneous landscapes. Maximizing expansion speed requires balancing exploration and exploitation, leading to an optimal intermediate switching rate in these spatial settings. Critically, we incorporate a phenotypic switching lag, representing the biophysical cost of adaptation. We demonstrate this lag imposes a hard fitness constraint, forcing the optimal strategy toward slower switching rates as lag duration increases and reducing maximum expansion speed. Contrasting with models focusing on irreversible mutations, we show reversible switching enhances resilience by allowing recovery from maladaptation, influencing specialist persistence boundaries. Spatial structure also generates emergent phenomena: we find clustering provides collective protection, enhancing the survival of disadvantaged phenotypes. Additionally, our simulations show that conditioning on lineage survival alone is sufficient to generate the apparent stagnancy of deleterious sectors reported experimentally, revealing this observational bias as a crucial factor when characterizing selection effects at expanding fronts. This work integrates bethedging theory with adaptation costs and spatial dynamics, offering a quantitative framework for fitness at expanding fronts.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.251
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

Explore more

Same venuebioRxiv (Cold Spring Harbor Laboratory)→Same topicEvolution and Genetic Dynamics→French-language works237,207→