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Mental disorder comorbidity in children and youth with chronic physical illness: A 48-month follow-up

2025· article· en· W4415654273 on OpenAlexafffund
Mark A. Ferro, Christy K. Y. Chan, Dillon T. Browne, Laura Duncan, Scott T. Leatherdale, Joe Quadrilatero, Tolulope T. Sajobi, Brian W. Timmons, Alène Toulany

Bibliographic record

VenueJournal of Psychosomatic Research · 2025
Typearticle
Languageen
FieldMedicine
TopicChildhood Cancer Survivors' Quality of Life
Canadian institutionsHospital for Sick ChildrenUniversity of CalgaryUniversity of TorontoMcMaster UniversityUniversity of Waterloo
FundersCanadian Institutes of Health ResearchCanada Research Chairs
KeywordsComorbidityPsychopathologyPsychiatric comorbidityChild psychopathologyMental healthPrevalence of mental disorders

Abstract

fetched live from OpenAlex

BACKGROUND: Few studies investigate longer-term continuity of mental disorder among children and youth with chronic physical illness. OBJECTIVES: This study examined the prevalence and predictors of homotypic and heterotypic continuity of mental disorder in children and youth with chronic physical illness. METHODS: Children and youth (2-16 years) with physical illness were recruited from outpatient clinics at a pediatric hospital (N = 263) and followed for 48 months. Mental disorder was assessed using the Mini International Neuropsychiatric Interview for Children and Adolescents. Generalized estimating equations were computed to identify clinical, parent, and demographic predictors of continuity. RESULTS: Mental disorder was observed in 24 %-38 % (child-report) and 35 %-39 % (parent-report) of children and youth. Prevalence increased from baseline to 48 months for child-reports (p < 0.05). Child-reported models revealed significant homotypic continuity for mood (OR = 5.5 [2.4, 12.9]) and anxiety disorder (OR = 5.4 [2.3, 12.8]), and heterotypic continuity between baseline anxiety and subsequent mood disorder (OR = 6.1 [2.5, 14.5]), and baseline mood and subsequent anxiety disorder (OR = 2.5 [1.1, 5.8]). Parent-reported models revealed significant homotypic continuity for all disorders (ORs = 2.6-7.7), and heterotypic continuity between baseline mood and subsequent anxiety disorder (OR = 2.4 [1.3, 4.7]), baseline anxiety disorder/ADHD and subsequent behavior disorder (OR = 2.7 [1.1, 6.9]/OR = 4.9 [2.0, 11.8]), and baseline behavior and all mental disorders (ORs = 3.5-9.4). Child/youth disability (ORs = 1.2-1.4) and parent psychopathology (ORs = 1.1-1.5) were consistent predictors of continuity. CONCLUSIONS: Mental disorder is prevalent and persistent in children and youth with physical illness. Child/youth disability and parent psychopathology may be priority targets to prevent and screen for physical-mental comorbidity in children and youth.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.022
Threshold uncertainty score0.043

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.398
Teacher spread0.362 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2025
Admission routes2
Has abstractyes

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