Long term immunogenicity of two doses of the quadrivalent HPV vaccine and the effect of an additional dose given five years post-primary vaccination
Bibliographic record
Abstract
BACKGROUND: Antibody persistence in girls (age 9-11 years) receiving two quadrivalent vaccine (4vHPV) doses and impact of an additional dose five years post-primary vaccination were assessed. METHODS: Girls vaccinated with two 4vHPV (Gardasil) doses (n = 496) were randomized to one- (2 + 1) or no-additional-dose groups five years post-first dose. Geometric mean concentrations (GMCs) for HPV types 6/11/16/18 were measured using M9ELISA at 5, 7.5, and 10 years post-primary vaccination. RESULTS: Antibodies to 4vHPV-targeted types persisted in all participants at each time point in both study arms. Compared to the 2-dose group that had stable antibody levels up to 10 years, GMCs were higher in the 2 + 1 group at 7.5 and 10 years post-primary vaccination (p < .0001). CONCLUSIONS: Two doses of 4vHPV administered at ages 9-11 confers stable antibody levels up to 10 years post-vaccination that can be enhanced with an additional dose given several years later, suggesting the presence of immune memory.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".