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Record W4415685397 · doi:10.3389/fbioe.2025.1671344

Explainable artificial intelligence for gait analysis: advances, pitfalls, and challenges - a systematic review

2025· review· en· W4415685397 on OpenAlexaff
Liangliang Xiang, Zixiang Gao, Peimin Yu, Justin Fernandez, Yaodong Gu, Ruoli Wang, Elena M. Gutierrez-Farewik

Bibliographic record

VenueFrontiers in Bioengineering and Biotechnology · 2025
Typereview
Languageen
FieldHealth Professions
TopicBalance, Gait, and Falls Prevention
Canadian institutionsUniversity of Calgary
FundersStiftelsen Promobilia
KeywordsInterpretabilityGaitRelevance (law)Gait analysisStandardizationTransparency (behavior)

Abstract

fetched live from OpenAlex

Machine learning (ML) has emerged as a powerful tool to analyze gait data, yet the "black-box" nature of many ML models hinders their clinical application. Explainable artificial intelligence (XAI) promises to enhance the interpretability and transparency of ML models, making them more suitable for clinical decision-making. This systematic review, registered on PROSPERO (CRD42024622752), assessed the application of XAI in gait analysis by examining its methods, performance, and potential for clinical utility. A comprehensive search across four electronic databases yielded 3676 unique records, of which 31 studies met inclusion criteria. These studies were categorized into model-agnostic (n = 16), model-specific (n = 12), and hybrid (n = 3) interpretability approaches. Most applied local interpretation methods such as SHAP and LIME, while others used Grad-CAM, attention mechanisms, and Layer-wise Relevance Propagation. Clinical populations studied included Parkinson's disease, stroke, sarcopenia, cerebral palsy, and musculoskeletal disorders. Reported outcomes highlighted biomechanically relevant features such as stride length and joint angles as key discriminators of pathological gait. Overall, the findings demonstrate that XAI can bridge the gap between predictive performance and interpretability, but significant challenges remain in standardization, validation, and balancing accuracy with transparency. Future research should refine XAI frameworks and assess their real-world clinical applicability across diverse gait disorders.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.319
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0030.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.041
GPT teacher head0.352
Teacher spread0.311 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueFrontiers in Bioengineering and BiotechnologySame topicBalance, Gait, and Falls PreventionFrench-language works237,207