Characterization of Hydrophobic and Polar Binding Environments in a Sodium Deoxycholate Hydrogel Using Fluorescence and Photochromism
Bibliographic record
Abstract
The properties of guests bound to sodium deoxycholate (NaDC) gels was compared to the properties NaDC self-assemblies in solution to determine the extent of the similarities of these properties in the solution and gel phases. Bile salts, such as NaDC, form self-assemblies with two binding sites with different properties and guests that bind to the self-assemblies were chosen to determine these different properties. Pyrene and perylene were used as fluorescent probes that reside in the primary aggregates of NaDC self-assemblies, while the photochromism of 1′,3′,3′-trimethyl-6-nitrospiro[2H-1]-benzopyran-2,2′-indoline was used to probe the binding site in the larger secondary aggregates. The properties reported by all three guests showed that the properties for the two different binding sites were the same for NaDC self-assemblies in solution and in the gel. These results will be instrumental for the design of gel systems containing bile salts since the properties observed for guests in the self-assemblies in solution are directly transferable to the immobile phase of the gel.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".