Effect of supplying a portion of trace mineral amino acid complexes on serum folate concentration from the dry period to early lactation
Bibliographic record
Abstract
Folates are required in one-carbon metabolism and DNA methylation. During the transition period, these roles are particularly important for the final stages of fetal development and the onset of lactation. The objective of this retrospective study was to assess plasma folate concentration when a portion of dietary inorganic chloride trace minerals (ITM) and cobalt (Co) carbonate was replaced by AA complexes of trace minerals (AATM) and Co glucoheptonate during the transition period. Relationships between serum folate concentration and health biomarkers were also evaluated. With dietary trace mineral concentrations being the same between treatments, a total of 36 Holstein multiparous cows were randomly assigned based on their parity number and previous 305-d mature equivalent milk production to either (1) an ITM blend consisting of zinc (75 mg/kg DM), manganese (65 mg/kg), and copper (10 mg/kg) as hydroxychlorides, and cobalt (1 mg/kg) as carbonate (ITM) or (2) partial replacement of ITM with AATM of Zn (40 mg/kg), Mn (20 mg/kg), Cu (3.5 mg/kg), and Co glucoheptonate (1 mg/kg; AATM, Availa-Dairy, Zinpro Corp.) from 1 wk after dry-off through 8 wk of lactation. Milk yields were recorded at each milking. Blood samples were taken at wk -8 (before treatment administration), -1, 1, 2, and 8 relative to parturition for serum folate analysis. Serum folate concentration from wk -1 to 8 relative to parturition averaged 8.39 (SE: 0.44) ng/mL and was not affected by treatments. Regardless of treatments, serum folate concentration significantly decreased from wk -8 to -1, plateaued from wk -1 to 2 relative to parturition, and then significantly increased through wk 8 of lactation. Milk yield, DMI, serum alanine aminotransferase, and alkaline phosphatase concentrations were positively correlated with serum folate concentration, whereas serum BHB concentration tended to be negatively correlated with serum folate concentration. In conclusion, in the current study, the source of the trace mineral supplement fed during the dry period and early lactation did not have an impact on serum folate concentrations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".