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Prevalence and pathological features of canine mammary tumors

2025· article· W4415759421 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueInternational Journal of Advanced Biochemistry Research · 2025
Typearticle
Language
FieldMedicine
TopicVeterinary Oncology Research
Canadian institutionsnot available
Fundersnot available
KeywordsPathologicalMammary glandMammary carcinomaAdenomaHyperplasiaCytologyMammary tumorHistopathological examination

Abstract

fetched live from OpenAlex

The present study examined 50 spontaneous canine mammary tumors to assess their distribution based on age, breed, and glandular involvement, along with their gross, cytological, and histopathological features. Mammary tumors were most frequently observed in middle-aged female dogs, with a mean age of eight years and a peak incidence between six and eight years. Labrador Retrievers were the most commonly affected breed, followed by non-descriptive breeds, Golden Retrievers, and Dachshunds. All affected dogs were females, predominantly intact, indicating a strong hormonal influence in tumor development. The caudal abdominal and inguinal glands, especially on the left mammary chain, were the most frequently involved sites. Grossly, the tumors varied from well-circumscribed solitary nodules to large, multifocal, ulcerated, or cystic masses. Malignant tumors accounted for 70% of the total cases, while benign and hyperplastic lesions comprised the remainder. Cytological evaluation of malignant tumors revealed high cellularity, marked pleomorphism, and a high nuclear-to-cytoplasmic ratio, whereas benign tumors exhibited cellular uniformity and low mitotic activity. Histopathologically, tubular carcinoma was the most prevalent malignant subtype, followed by complex and cystic papillary carcinomas, while simple adenomas were the most common benign lesions. The observed histological patterns were consistent with established classifications of canine mammary neoplasia, validating the use of cytology as a reliable diagnostic tool. Overall, the findings emphasize that spontaneous mammary tumors are common in intact, middle-aged female dogs, with the caudal mammary glands being the most affected sites, highlighting the importance of early cytological screening and histopathological evaluation for accurate diagnosis and management of canine mammary neoplasia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.007
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesResearch integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.281
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.002
Scholarly communication0.0000.000
Open science0.0020.001
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.446
Teacher spread0.407 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it