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Record W4415778159 · doi:10.2471/blt.24.292879

A global approach to safety assessment of medicinal plants

2025· article· en· W4415778159 on OpenAlexaboutno aff
Bhushan Patwardhan, Sarika Chaturvedi, J. Hunter, L. Susan Wieland, Nessma El-Nabawy, Anchalee Chuthaputti, Kofi Donkor, Kim Sungchol, Evelyn Wolfram, Geetha Krishnan Gopalakrishna Pillai, Shyama Kuruvilla

Bibliographic record

VenueBulletin of the World Health Organization · 2025
Typearticle
Languageen
FieldMedicine
TopicHerbal Medicine Research Studies
Canadian institutionsnot available
FundersWorld Health Organization
KeywordsMedicinal plantsMEDLINE

Abstract

fetched live from OpenAlex

Establishing a robust global framework for assessing the safety of plants used for medicinal purposes (medicinal plants) is complex. Unlike synthetic drugs, plant-based products often lack standardized codification, quantification or context-specific usage data. Medicinal plant products are classified differently worldwide: in some countries (such as in the United States of America), they are treated as foods or dietary supplements unless manufacturers make therapeutic claims; in other jurisdictions, geographic areas and countries (such as in the European Union, the Asian continent, Australia or Canada), they are regulated as low-risk medicines. Different jurisdictions vary widely in cultural acceptance or bias towards medicinal plant use. This fragmented landscape results in inconsistent safety standards, reporting protocols and access to markets for practitioners, patients and consumers.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.960
Threshold uncertainty score0.276

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.002
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.373
Teacher spread0.356 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes1
Has abstractyes

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