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Record W4415782739 · doi:10.1101/2025.10.31.25338992

The Canadian multi-ethnic research on aging (CAMERA) study: Study design, participant characteristics, and preliminary findings

2025· preprint· W4415782739 on OpenAlexafffundabout
Tulip Marawi, Harleen Rai, Rohina Kumar, Katie L. Vandeloo, Rachel Yep, Madeline Wood Alexander, Silina Z. Boshmaf, Shuning Chen, Georgia Gopinath, Alexander Nyman, Tallinn F. L. Splinter, Douglas P. Munoz, Walter Swardfager, Jennifer D. Ryan, Sandra E. Black, Maged Goubran, Jennifer S. Rabin

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Language
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsSunnybrook HospitalHealth Sciences CentreBaycrest HospitalQueen's UniversityKingston Health Sciences CentreThe Scarborough HospitalSunnybrook Health Science CentreToronto Rehabilitation InstituteUniversity of Toronto
FundersNational Institutes of HealthCanada Research ChairsEli Lilly and CompanyAlzheimer SocietyCanadian Institutes of Health ResearchWeston Brain InstituteBiogenFondation LeducqFondation Brain CanadaHeart and Stroke Foundation of CanadaNovo NordiskEisaiAlzheimer's Association
KeywordsDementiaObservational studyCognitionPsychological resilienceMontreal Cognitive AssessmentCognitive impairmentSouth asiaLongitudinal study

Abstract

fetched live from OpenAlex

Abstract INTRODUCTION South Asian and Chinese individuals are the largest and fastest-growing ethnoracial groups in Canada, yet they remain underrepresented in dementia research. To address this gap, we established the CA nadian M ulti- E thnic R esearch on A ging (CAMERA) study. METHODS CAMERA is a longitudinal observational study conducted in Toronto, Canada, enrolling 300 adults aged 55–85 who self-identify as South Asian, Chinese, or non-Hispanic White (NHW). Participants complete in-person visits at baseline, Year 3, and Year 5, which include clinical and cognitive assessments, brain MRI, and blood biomarkers. Annual remote questionnaires track health and lifestyle. RESULTS Among 200 participants, vascular and metabolic profiles differed across groups. South Asian and Chinese participants reported greater cognitive concerns than NHW participants and had lower MoCA scores, driven primarily by language-heavy and culturally dependent items. Eye-tracking measures did not differ across groups. DISCUSSION CAMERA provides a deep phenotyping framework to investigate dementia risk and resilience in Asian Canadians.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.006
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.026
Threshold uncertainty score0.190

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0060.006
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.005
Science and technology studies0.0090.001
Scholarly communication0.0020.001
Open science0.0030.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.297
GPT teacher head0.469
Teacher spread0.172 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes3
Has abstractyes

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Same venuemedRxiv→Same topicDementia and Cognitive Impairment Research→French-language works237,207→