Abstract 4362546: Non-Contrast Coronary Artery Imaging with a Novel High Frequency Optical Coherence Tomography
Bibliographic record
Abstract
Background: Intracoronary optical coherence tomography (OCT) is widely utilized for high-resolution imaging of coronary arteries, but it requiring contrast agents to displace blood from the imaging field. Accordingly, concerns have arose regarding the potential adverse effects of an additional use of contrast medium particularly in patients with renal dysfunction and heart failure, which may limit the widespread use of OCT. Research Qustions: This study evaluates the feasibility and safety of isotonic electrolyte solution, lactated Ringer’s solution (LRS), as a flushing medium for a novel fast-pullback, high-frequency optical coherence tomography imaging system (HF-OCT, Gentuity, Sudbury, MA). Methods: This prospective study enrolled 21 patients with stable coronary artery disease (CAD), and 52 pairs of OCT imaging were evaluated. HF-OCT imaging was sequentially performed using either a contrast agent (iohexol 350, group C) or LRS (group LRS) as the flushing medium. To evaluate the efficacy of blood clearance, clear imaging length (CIL) index was used, which was defined as the segment with a visible lumen-to-vessel wall boundary over at least 270 degrees. Quantitative and qualitative OCT image analyses were also compared between the two groups. Results: The success rate of the first OCT imaging was 98.1% in group C, and 92.3% in group LRS. The injection volume used in each imaging was 5.0 +/- 0ml in group C and 18.9+/-1.5 ml in group LRS, respctively (p<0.05). CIL (mm) and CIL (%) were similar between the two groups (median 81.0 mm, interquartile range (IQR) 74.5-92.0 vs. median 79.2 mm, IQR 68.8-89.6, p=0.526 and median 100%, IQR 100-100 vs. median 100, IQR 99-100, respectively). Quantitative OCT parameters, i.e., minimum lumen area and diameter, were comparable between groups (median 2.75 smm, IQR 1.85-4.48, vs. 2.85 mms, IQR 2.03-4.58, p=0.654, and median 1.85 mm, IQR 1.53-2.40, vs. 1.90 mm, IQR 1.60-2.40, p=0.651, respectively). Qualitative OCT findings, such as presence of a lipid-rich plaque, thin-cap fibroatheroma, and macrophages, were equally visualized using both flushing media. No adverse events during imaging was observed in both groups. Conclusions: HF-OCT imaging using isotonic electrolyte solusion (LRS) as a flushing medium is safe and effective, while maintaining comparable lesion assessment to contrast-based OCT imaging. This technique may be beneficial for the OCT-guided PCI in wide-range of CAD patients including renal dysfunction.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".