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Record W4415835012 · doi:10.1038/s42004-025-01731-8

From melanogenesis to melanin technologies

2025· review· en· W4415835012 on OpenAlexafffund
Noah Al‐Shamery, Dauren Biyashev, Lluı́s Blancafort, Anthony Camus, Nathan C. Gianneschi, Carlos F. O. Graeff, Bern Kohler, Shujie Li, Kurt Q. Lu, Jean‐Philip Lumb, Paola Manini, Maria E. McNamara, Paul Meredith, A. Bernardus Mostert, Toby L. Nelson, Buşra Özlü, Valentina Rossi, Farhana Shanta, Matthew D. Shawkey, Bong Sup Shim, Andrew J. Surman, Wanjie Xie, Clara Santato, Micaela Matta

Bibliographic record

VenueCommunications Chemistry · 2025
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
Topicmelanin and skin pigmentation
Canadian institutionsMcGill UniversityPolytechnique Montréal
FundersChina Scholarship CouncilOffice of Energy EfficiencyBiotechnology and Biological Sciences Research CouncilNatural Sciences and Engineering Research Council of CanadaEuropean Office of Aerospace Research and DevelopmentMinisterio de Ciencia e InnovaciónOffice of Energy Efficiency and Renewable EnergyU.S. Department of EnergyNanyang Technological UniversityRoyal SocietyUK Research and InnovationAir Force Office of Scientific Research
KeywordsMelaninPerspective (graphical)Supramolecular chemistryNatural (archaeology)Key (lock)

Abstract

fetched live from OpenAlex

Melanins are a diverse family of natural pigments with a unique combination of optical, electronic, redox, and structural properties that challenge conventional chemical characterisation. This Perspective summarises key insights from the first international interdisciplinary meeting dedicated to melanin, held in Eastbourne, UK and sponsored by the Royal Society. The meeting brought together advances in melanogenesis, pigment evolution, molecular and supramolecular melanin characterisation, alongside emerging applications in energy storage, sensing, coatings, and biodegradable electronics. Here, we highlight the fragmentation of melanin research across disciplines and advocate for a unified, interdisciplinary approach to understanding melanin's complex chemistry. By integrating perspectives from experts in biology, materials science, paleontology, device physics and chemistry, we propose a roadmap for future melanin research, towards melanin-based functional devices and technologies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0020.001
Science and technology studies0.0000.001
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0030.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.037
GPT teacher head0.364
Teacher spread0.327 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2025
Admission routes2
Has abstractyes

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