MétaCan
Menu
Back to cohort

64 A novel application of selective exo-enzymatic glycan labeling to co-quantify cell-surface glycans and protein-based biomarkers of the tumour immune microenvironment

2025· article· W4415900069 on OpenAlexaff
Katherine C. Brewer, Fabiola V. De León González, A. Uriarte, Eman R. Radwan, Xiaojing J Gou, Andrew D McLellan, Jonathan L. Babulic, Tricia R. Cottrell, Chantelle J. Capicciotti

Bibliographic record

VenueRegular and Young Investigator Award Abstracts · 2025
Typearticle
Language
FieldBiochemistry, Genetics and Molecular Biology
TopicGlycosylation and Glycoproteins Research
Canadian institutionsQueen's University
Fundersnot available
KeywordsGlycanImmune systemTumor microenvironmentCell

Abstract

fetched live from OpenAlex

64 Figure 1 Determining tolerance of selective exo-enzymatic glycan labeling of SK-BR-3 cell surface glycans to formalin fixation and paraffin embedding preservation.SEEL of N-glycans by ST6Gal1 (1a,b) on SK-BR-3 breast cancer cells subject to FFPE (1c) remains robust and comparable to live cell controls as determined by flow cytometry (1d,e)

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.033
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.248
Teacher spread0.241 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueRegular and Young Investigator Award AbstractsSame topicGlycosylation and Glycoproteins ResearchFrench-language works237,207