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Robotic-assisted total knee arthroplasty with MAKO is associated with improved functional outcomes

2025· review· en· W4415939594 on OpenAlex
Kabir Sodhi, Jacob Eaton-Brown, Prakrit Raj Kumar, Oluwasemilore Adebayo, Henry Searle, Andrew Metcalfe, Edward T. Davis, Chetan Khatri

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueBone & Joint Open · 2025
Typereview
Languageen
FieldMedicine
TopicTotal Knee Arthroplasty Outcomes
Canadian institutionsnot available
FundersUniversity of Warwick
KeywordsTotal knee arthroplastyRandomized controlled trialArthroplastyClinical trialFunctional data analysis

Abstract

fetched live from OpenAlex

Aims: To improve functional outcomes following total knee arthroplasty (TKA), robotic systems have been introduced such as the MAKO (Stryker), the most widely used system globally at present. This systematic review aimed to compare the patient-reported outcome measures (PROMs) of robotic TKA (RTKA) to manual TKA (MTKA). Methods: Five electronic databases were systematically searched for eligible articles that used PROMs to compare MAKO RTKA to MTKA. The primary outcome was the Forgotten Joint Score (FJS). We defined follow-up periods as short (up to three months), medium (three months to one year), and long term (beyond one year). We pooled outcomes combining the Knee Society Scoring System (KSS), Oxford Knee Score (OKS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Meta-analyses were conducted using a random-effects model and reported using mean difference (MD) or standardized mean difference (SMD) and 95% CI. Results: In total, 22 articles evaluating 3,738 TKAs were included: 1,835 MTKAs and 1,903 RTKAs. The evidence level for most studies were IIa, due to few high-level studies. Using FJS, meta-analysis showed little difference at short-term follow-up (MD 11.49, 95% CI -5.62 to 28.59), but found a difference at medium-term follow-up (MD 5.50, 95% CI 2.19 to 8.81). This was not sustained at long-term follow-up (MD 23.89, 95% CI -16.50 to 64.27). Pooling all PROMs showed no difference in the short term (SMD 0.27, 95% CI -0.05 to 0.59), but results favoured RTKA at medium- (SMD 0.46, 95% CI 0.22 to 0.70) and long-term follow-up (SMD 0.40, 95% CI 0.13 to 0.66). Conclusion: There are few high-level studies, but based on current data MAKO RTKA may result in improved functional outcomes compared to MTKA. Further randomized controlled trials are required to provide robust data and to assess clinical and cost-effectiveness as well as a wider spectrum of early and late outcomes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesMeta-epidemiology (narrow)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.897
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0060.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.049
GPT teacher head0.303
Teacher spread0.254 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it