Long-Term Production and Reproductive Outcomes in Dairy Calves Following Early-Life Ultrasonographic Lung Consolidation: A Longitudinal Follow-Up Study
Bibliographic record
Abstract
Bovine respiratory disease is a significant health concern in dairy calves, impacting short-term growth and potentially long-term productivity. While previous studies have linked early-life lung consolidation, often subclinical and diagnosed by lung ultrasonography, to reduced preweaning average daily gain, its extended effects on production and reproductive parameters remain less studied, particularly in specific geographical contexts. This study presents a follow-up analysis on a cohort of dairy calves originally monitored weekly from birth to weaning for lung consolidation via TUS in an Iranian dairy herd. Two years post-weaning, comprehensive production and reproduction data were collected and analyzed for these same animals. Our objective was to investigate the long-term associations between early-life lung consolidation and subsequent outcomes, including mature equivalent milk yield, corrected milk yield, culling risk before and during lactation, age at first breeding, age at first calving, and reproduction parameters such as services per conception and conception rate (the percentage of cows or heifers that become pregnant after a single insemination or breeding attempt). Data analysis, employing descriptive statistics, survival analysis, and non-parametric tests, revealed that while early-life lung consolidation (defined by ≥1 cm or ≥3 cm depth, and number of episodes) did not show significant associations with culling probability or mature equivalent milk yield, interesting numerical trends were observed. The study highlights the complexities of establishing clear long-term links, suggesting that while subclinical BRD can have immediate growth impacts, its chronic effects on later production and reproduction may be subtle and require larger cohorts or more targeted analysis to achieve statistical significance. The findings reinforce the need for cautious interpretation of p-values in the context of multiple comparisons and underscore the challenges in quantifying long-term economic consequences of early-life respiratory health.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".