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Record W4415970833 · doi:10.1126/science.adx2022

Postdomestication selection of MKK3 shaped seed dormancy and end-use traits in barley

2025· article· en· W4415970833 on OpenAlexfundno aff
Morten Egevang Jørgensen, Dominique Vequaud, Yucheng Wang, Christian B. Andersen, Micha Bayer, Amanda Box, Katarzyna Braune, Yuanyang Cai, Fahu Chen, J.A. Cuesta-Seijo, Haoran Dong, Geoffrey B. Fincher, Zoran Gojković, Zihao Huang, Benjamin Jaegle, Sandip M. Kale, Flavia Krsticevic, Pierre-Marie Le Roux, Antoine Lozier, Qiongxian Lu, Martin Mascher, Emiko Murozuka, Shingo Nakamura, Martin Toft Simmelsgaard Nielsen, Pai Pedas, Pierre A. Pin, Dagmara Podzimska‐Sroka, Kazuhiro Sato, M. Spannagl, Magnus Wohlfahrt Rasmussen, Joanne Russell, Miriam Schreiber, Hanne Cecilie Thomsen, Nina W. Thomsen, Sophia Tulloch, Cynthia Voss, Birgitte Skadhauge, Nils Stein, Eske Willerslev, Robbie Waugh, Christoph Dockter

Bibliographic record

VenueScience · 2025
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicSeed Germination and Physiology
Canadian institutionsnot available
FundersOpen Research Fund of Key Laboratory of Digital Earth ScienceBiotechnology and Biological Sciences Research CouncilHORIZON EUROPE Framework ProgrammeAgricultural Research ServiceJapan Society for the Promotion of ScienceNovo Nordisk FondenBundesministerium für Bildung und ForschungCarlsbergfondetEuropean CommissionUniversity of MinnesotaJames Hutton InstituteUniversity of SaskatchewanNational Natural Science Foundation of ChinaRural and Environment Science and Analytical Services DivisionLeibniz-GemeinschaftInnovationsfondenDanmarks GrundforskningsfondU.S. Department of Agriculture
KeywordsPreharvestDormancySeed dormancyIdeotypeSproutingSelection (genetic algorithm)

Abstract

fetched live from OpenAlex

Anthropogenic selection of grain traits such as dormancy has shaped the developmental trajectories of crops. In cereals, shortening dormancy provides rapid and even postharvest germination, but increases the risk of weather-induced preharvest sprouting, with yearly harvest losses beyond 1 billion dollars. Our understanding of how, why, when, and where cereal dormancy diversification arose is fragmentary. Here, we show in the founder crop barley ( Hordeum vulgare ) that dormancy is primarily regulated through a mosaic of locus haplotypes comprising copy number variation and inherent kinase activity of Mitogen-activated protein kinase kinase 3 ( MKK3 ). We provide evidence supporting the historical selection of specific MKK3 haplotypes that shaped dormancy levels according to changing climatic pressures and outline a genetic framework for breeders to balance grain dormancy and preharvest sprouting avoidance.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.257
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes1
Has abstractyes

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