Far UV synchrotron radiation circular dichroism of guanine nucleosides
Bibliographic record
Abstract
Synchrotron radiation circular dichroism spectra of 2'-deoxyribonucleosides, as well as a few guanine nucleosides were recorded between 170-330 nm. The CD profile of each nucleoside is unique, and there is a general similarity in the SRCD patterns of deoxyribonucleosides and those recorded by a benchtop CD as previously reported. Furthermore, the locked nucleic acid derivative of guanine nucleoside (LNA-G) showed opposite CD profiles to the rest of the guanine nucleoside derivatives. The conformational parameters of the nucleosides were analyzed against the crystal structures available in the Cambridge Crystallographic Data Center. The pseudorotational phase angles of the guanine nucleoside derivatives in solution were also determined based on NMR coupling constants. Analyses showed no apparent correlation between pseudorotational phase angles and CD patterns.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".