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Record W4415988375 · doi:10.1038/s41746-025-02035-w

A generalizable 3D framework and model for self-supervised learning in medical imaging

2025· article· en· W4415988375 on OpenAlexafffund
Tony Xu, Sepehr Hosseini, Chris Anderson, Anthony Rinaldi, Rahul G. Krishnan, Anne L. Martel, Maged Goubran

Bibliographic record

Venuenpj Digital Medicine · 2025
Typearticle
Languageen
FieldComputer Science
TopicDomain Adaptation and Few-Shot Learning
Canadian institutionsHealth Sciences CentreVector InstituteSunnybrook Health Science CentreUniversity of Toronto
FundersGoogle ResearchNational Institute of Mental HealthNational Institute on AgingFaculty of Health Sciences, Queen's UniversityNational Institute of Biomedical Imaging and BioengineeringCanadian Institutes of Health ResearchUniversity of California, Los AngelesGenentechNational Institutes of HealthH. Lundbeck A/SServierTemerty Family FoundationEisaiMcDonnell Center for Systems NeuroscienceQueen's UniversityUniversity of OttawaCanada Research ChairsNatural Sciences and Engineering Research Council of CanadaBioClinicaBiogenPfizerCentre for Addiction and Mental Health FoundationIXICOAlliance de recherche numérique du CanadaBristol-Myers SquibbGovernment of OntarioLondon Health Sciences FoundationNorthern California Institute for Research and EducationMcMaster UniversityNovartis Pharmaceuticals CorporationEli Lilly and CompanyNational Center for Advancing Translational SciencesMeso Scale DiagnosticsAlzheimer's Disease Neuroimaging InitiativeAlzheimer's AssociationFoundation for the National Institutes of Health
KeywordsGeneralizability theoryMedical imagingLimitingPretextVisualizationMedical diagnosis

Abstract

fetched live from OpenAlex

Current self-supervised learning (SSL) methods for 3D medical imaging rely on simple pretext formulations and organ- or modality-specific datasets, limiting their generalizability and scalability. We present 3DINO, a cutting-edge SSL method adapted to 3D datasets, and pretrain 3DINO-ViT: a general-purpose model for medical imaging, on a ultra-large multimodal dataset of ~100,000 3D scans from over 10 organs. We show 3DINO-ViT outperforms state-of-the-art pretrained models on numerous downstream imaging tasks.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.006
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.004
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.002
Open science0.0040.003
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0020.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.282
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations12
Published2025
Admission routes2
Has abstractyes

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