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Record W4415988375 · doi:10.1038/s41746-025-02035-w

A generalizable 3D framework and model for self-supervised learning in medical imaging

2025· article· en· W4415988375 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

Venuenpj Digital Medicine · 2025
Typearticle
Languageen
FieldComputer Science
TopicDomain Adaptation and Few-Shot Learning
Canadian institutionsHealth Sciences CentreVector InstituteSunnybrook Health Science CentreUniversity of Toronto
FundersGoogle ResearchNational Institute of Mental HealthNational Institute on AgingFaculty of Health Sciences, Queen's UniversityNational Institute of Biomedical Imaging and BioengineeringCanadian Institutes of Health ResearchUniversity of California, Los AngelesGenentechNational Institutes of HealthH. Lundbeck A/SServierTemerty Family FoundationEisaiMcDonnell Center for Systems NeuroscienceQueen's UniversityUniversity of OttawaCanada Research ChairsNatural Sciences and Engineering Research Council of CanadaBioClinicaBiogenPfizerCentre for Addiction and Mental Health FoundationIXICOAlliance de recherche numérique du CanadaBristol-Myers SquibbGovernment of OntarioLondon Health Sciences FoundationNorthern California Institute for Research and EducationMcMaster UniversityNovartis Pharmaceuticals CorporationEli Lilly and CompanyNational Center for Advancing Translational SciencesMeso Scale DiagnosticsAlzheimer's Disease Neuroimaging InitiativeAlzheimer's AssociationFoundation for the National Institutes of Health
KeywordsGeneralizability theoryMedical imagingLimitingPretextVisualizationMedical diagnosis

Abstract

fetched live from OpenAlex

Current self-supervised learning (SSL) methods for 3D medical imaging rely on simple pretext formulations and organ- or modality-specific datasets, limiting their generalizability and scalability. We present 3DINO, a cutting-edge SSL method adapted to 3D datasets, and pretrain 3DINO-ViT: a general-purpose model for medical imaging, on a ultra-large multimodal dataset of ~100,000 3D scans from over 10 organs. We show 3DINO-ViT outperforms state-of-the-art pretrained models on numerous downstream imaging tasks.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.965
Threshold uncertainty score0.467

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.282
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it