Assessment of toxicity in patients with ultra-central thoracic tumours treated with stereotactic body radiotherapy with a dose of 50 Gy in 5 fractions
Bibliographic record
Abstract
Background: Stereotactic body radiotherapy (SBRT) is a well-accepted treatment for metastatic and primary lung cancer; however, an optimal regimen is still unclear for ultra central thoracic lesions. The objective of this manuscript is to report the toxicity of SBRT in patients with ultra-central tumors treated with 50 Gy in 5 fractions. Materials and methods: We performed a retrospective review of patients with ultra-central lung lesions treated with SBRT in our institution at the dose of 50 Gy in 5 fractions, delivered every other day. Lesions were defined as ultra-central when the planning target volume (PTV) overlapped the trachea, proximal bronchial tree, great vessels, heart and esophagus. Constraints for organ at risk (OAR) were the ones used in the RTOG-0813 trial. Results: 86 patients were included in this review. The median age was 74 years. The overlapping OAR were: the great vessels in 46 patients (53.4%), heart in 20 (23.2%), tracheobronchial tree in 18 (20.9%) and esophagus in 2 (2.3%). Median follow up was 17 months. The median overall survival was 39 months. There was no SBRT related grade 3 or greater acute or late toxicity. Conclusion: In this cohort of patients with ultra-central thoracic lesions treated with 50 Gy in 5 fraction SBRT, no grade 3-5 acute or late toxicity was observed.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".