Usefulness of 3D joint space width on weight-bearing CT in comparison with 2D joint space width on radiographs for predicting 24-month worsening of knee osteoarthritis pain and function in the MOST study
Bibliographic record
Abstract
Objective This study compared the predictive validity of three-dimensional joint space width (3D-JSW) on weight-bearing computed tomography (WBCT) versus two-dimensional joint space width at predetermined mediolateral locations (2D-JSW x ) on radiographs for worsening knee pain and physical function over 24 months. Design Data from 302 participants (425 knees) in the Multicenter Osteoarthritis Study (MOST) were analyzed. Baseline assessments included bilateral standing radiographs for 2D-JSW x and WBCT for 3D-JSW. Minimal clinically important worsening (MCIW) of pain (Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale) and function (20-meter walk, sit-to-stand, WOMAC function subscale) over 24 months was assessed. Logistic regression with generalized estimating equations (GEE) accounted for within-person correlation, and predictive validity was evaluated by comparing receiver operating characteristic (ROC) areas under the curves (AUC). Results Participants had a mean age of 63.2±8.9 years and body mass index (BMI) of 28.2±4.8 kg/m². Over 24 months, 38 knees exhibited worsening WOMAC pain, with no significant association for either 3D-JSW or 2D-JSW x . For WOMAC pain, 3D-JSW (AUC=0.578) was not superior to 2D-JSW x (AUC=0.511; difference: 0.067 (95% confidence interval (CI): -0.040, 0.175)). Similar results were noted for the 20-meter walk (difference: 0.003 (95% CI: -0.049, 0.055)), sit-to-stand test (difference: 0.014 (95% CI: -0.034, 0.062)), and WOMAC function (difference: -0.020 (95% CI: -0.091, 0.050)). Conclusions 3D-JSW on WBCT did not outperform 2D-JSW x on radiography for predicting knee pain and functional worsening. However, WBCT offers several advantages, including improved imaging capabilities, that may facilitate assessment of osteoarthritis in clinical practice and research.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.011 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".