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Record W4416024408 · doi:10.1016/j.jaccas.2025.105945

Initial Double Sequential External Defibrillation for Refractory Ventricular Fibrillation in Cardiac Sarcoidosis

2025· article· en· W4416024408 on OpenAlexaff
Peter Antevy, Anthony Robles, Charles Coyle, Kenneth Scheppke, Sheldon Cheskes

Bibliographic record

VenueJACC Case Reports · 2025
Typearticle
Languageen
FieldMedicine
TopicSarcoidosis and Beryllium Toxicity Research
Canadian institutionsSunnybrook HospitalSunnybrook Health Science Centre
Fundersnot available
KeywordsDefibrillationRefractory (planetary science)Ventricular fibrillationCardiac sarcoidosisFibrillationSarcoidosis

Abstract

fetched live from OpenAlex

BACKGROUND: Double sequential external defibrillation (DSED) has demonstrated improved outcomes for refractory ventricular fibrillation (VF). Whether "initial" DSED improves outcomes is an area of ongoing research. We present a case of successful resuscitation employing early DSED. CASE SUMMARY: A 65-year-old man with cardiac sarcoidosis experienced a witnessed out-of-hospital cardiac arrest. The emergency medical services team confirmed VF and delivered DSED as the initial shock. Resuscitation inclusive of multiple DSED shocks, advanced airway management, amiodarone, and esmolol resulted in a return of spontaneous circulation. Cardiac magnetic resonance imaging confirmed cardiac sarcoidosis, and the patient was discharged with full neurological recovery. DISCUSSION: This is to our knowledge the first case of DSED used as the initial defibrillation strategy for refractory VF in cardiac sarcoidosis. Initial DSED may offer substantial benefit for high-risk patients, supporting ongoing evaluation of protocols for earlier use of DSED. TAKE-HOME MESSAGE: DSED can be safely and effectively used as initial therapy in patients with refractory VF.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.385
Threshold uncertainty score0.669

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.044
GPT teacher head0.375
Teacher spread0.331 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueJACC Case ReportsSame topicSarcoidosis and Beryllium Toxicity ResearchFrench-language works237,207