Evolution of sociability: genome scans and gene validation
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Sociability, defined as individuals' tendencies to affiliate with conspecifics, has positive associations with fitness in animals as well as with health, well-being, and longevity in humans. Despite its importance, we still have limited information about natural genetic variation in sociability. As part of a long-term initiative to address this knowledge gap, we quantified changes in allele frequencies in adult fruit flies (Drosophila melanogaster) from lineages that we artificially selected to diverge in sociability. Based on our genomic analyses, we generated a short list of 226 single nucleotide polymorphisms (SNPs) representing 169 candidate genes influencing variation in sociability. We also made a shorter list of 41 SNPs from 36 genes that showed the largest average divergence between the low and high sociability lineages. Experiments using knockdowns of 19 of the candidate sociability genes revealed that 18 of them significantly affected sociability, though some effects were sex-specific. Our results provide important insights into a quantitative trait central to the lives of many animals including humans.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it