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A self-driving lab for discovering tunable and soluble organic lasers

2025· preprint· W4416095531 on OpenAlexafffund
Hyun Suk Park, Mahdi Mazaheri, Changhyeok Choi, Han Hao, Davide Avagliano, Eric S. Isbrandt, Buddhika S. B. Karunathilaka, Chihaya Adachi, Alán Aspuru‐Guzik

Bibliographic record

VenueChemRxiv · 2025
Typepreprint
Language
FieldMaterials Science
TopicLuminescence and Fluorescent Materials
Canadian institutionsCanadian Institute for Advanced ResearchVector InstituteUniversity of Toronto
FundersNatural Resources CanadaCanada First Research Excellence FundGovernment of OntarioUniversity of TorontoCanada Foundation for InnovationOntario Research Foundation
KeywordsLasing thresholdThiopheneOrganic moleculesFluorineLaserDensity functional theoryMolecule

Abstract

fetched live from OpenAlex

We have recently demonstrated the ability of using self-driving laboratories for AI-driven searches of new emitters for organic solid-state lasing devices. Our past workflow featured solubility challenges for such large molecular moieties. In this next-generation study, we returned to the drawing board to explore a family of compounds that were much solution processable and composed of a set of electronic cores that would give a broader color response. Out of 252 potential candidates, we selectively performed a comprehensive study exploring 51 fluorene-based A-B-A type organic laser oligomers, armed with our self-driving lab. The candidates ranged from simple hydrocarbon molecules to complex hetero atom-mixed molecules. As a result of this study, we highlight diketopyrrolopyrrole and benzodiazole derivatives for largely red-shifted emissions. Furthermore, we investigated the effect of color change from hetero atom permutation, fluorine addition, thiophene coupling, and a combination of fluorine addition and thiophene coupling. The computational study with density functional theory confirmed the experimental results.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.250
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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