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Record W4416119697 · doi:10.1101/2025.11.09.687529

LSTM-Attention-Guided Graph Neural Networks for Integrated Genotype–Environment Modeling in Maize Yield Prediction

2025· preprint· en· W4416119697 on OpenAlexaff
Amir Morshedian, Michael Domaratzki

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Mapping and Diversity in Plants and Animals
Canadian institutionsWestern University
Fundersnot available
KeywordsBipartite graphArtificial neural networkPrincipal component analysisEmbeddingGraphSimilarity (geometry)Pattern recognition (psychology)Yield (engineering)

Abstract

fetched live from OpenAlex

This paper presents a deep-learning framework that combines an LSTM, a graph neural network (GNN), and transformer-style attention to model genotype-environment (G×E) effects for maize yield prediction. Weather data for a growing season is summarized using LSTM and encoded into a 21-dimensional embedding that is used as the environment node feature; 437,214 SNPs are summarized into 548 principal components that instantiate genotype nodes. Multi-head attention dynamically weights the edges during message passing. Three architectures are compared: A (fully bipartite graph), B (A with intra-set top-k similarity within genotype and within environment), and C (B with a single learnable supernode readout that attends over all nodes after message passing). The joint representations feed a compact MLP for yield prediction. Using a forward-time split (2014-2021 train; 2022 test with unseen genotypes and unseen environments), performance improves monotonically from A to C: A (RMSE 2.7749, PCC 0.4115, R2 0.1693), B (2.3683, 0.6622, 0.4385), C (2.2120, 0.6945, 0.4823). Compared to A, C has a reduction in RMSE by 0.5629 (∼20.3%) and an increase in PCC by 0.283 (∼68.8%), indicating that global, content-adaptive aggregation promotes local G×E propagation. Performance of proposed approach remains consistent regardless of the number of genotypes per environment and has strong performance under variable or unbalanced genotype sampling expression across environments. The proposed approach is compared with methods from the Global G×E Prediction Competition and show that two of three architectures improve predictive performance, with the best architecture achieving a lower RMSE (2.2120) and a higher Pearson correlation (0.6945) than the competition-winning model.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.022
Threshold uncertainty score0.043

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.209
Teacher spread0.189 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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