Evaluating the Effect of Hypothyroidism on Basal Metabolic Rate and Body Temperature Regulation
Bibliographic record
Abstract
Background: Hypothyroidism is a clinical condition resulting from inadequate production of thyroid hormone, which is an important regulator of basal metabolic rate (BMR) and thermoregulation. Slow metabolism and altered thermogenesis experienced by hypothyroid patients may result in significant physiological disruption. This study aimed to evaluate the impact of hypothyroidism on body temperature regulation and BMR in adults with primary hypothyroidism. Methods: It was a cross-sectional analytical study conducted with 200 adults aged 25-50 years were enrolled, consisting of 100 hypothyroid patients and 100 age- and sex-matched healthy controls. The indirect calorimetry was used to measure the BMR, and the core body temperature was measured by digital thermometry in a controlled ambient condition. The chemiluminescent immunoassay was used to measure thyroid function, including thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4). Independent t-test was used to measure continuous variables, and chi-square test for categorical variables through SPSS. p < 0.05 was considered statistically significant. Results: The hypothyroid group demonstrated lower BMR compared to controls (1195.8 ± 105.4 kcal/day vs. 1362.7 ± 112.3 kcal/day; p < 0.001). A decrease in core body temperature was also observed (p < 0.001). There was a significant alteration in thyroid hormone levels with increased TSH (9.22 ± 2.1 IU/mL) and decreased free T3 (2.12 ± 0.5 pg/mL) and T4 (0.62 ± 0.2 ng/dL) in the hypothyroid group (all p < 0.001). Conclusion: Hypothyroidism significantly diminishes metabolism rate and affects thermoregulation, highlighting that diagnosis and intervention are necessary.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".