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Record W4416332414 · doi:10.58931/cdet.2025.3346

Youth-Onset Type 2 Diabetes: A Review

2025· article· W4416332414 on OpenAlexafffundabout
M. Constantine Samaan

Bibliographic record

VenueCanadian Diabetes & Endocrinology Today · 2025
Typearticle
Language
FieldBiochemistry, Genetics and Molecular Biology
TopicDiabetes and associated disorders
Canadian institutionsQueen's University
FundersCanadian Institutes of Health Research
KeywordsType 2 diabetesObesityDiseaseDiabetes mellitusIncidence (geometry)PandemicNatural historyEthnic group

Abstract

fetched live from OpenAlex

Type 2 diabetes (T2D) was once considered a disease of adults. However, the obesity pandemic has helped its transition to the pediatric population. While type 1 diabetes remains the most common type of pediatric diabetes in Canada, the incidence of youth-onset T2D has increased by 60% in recent years. Canada has one of the highest prevalences of youth-onset T2D in the world, with approximately 50% of new cases annually occurring in Indigenous children, with the remaining 50% of cases occurring in other ethnic groups, including Caucasians. As a relatively new disease in youth, there is a lack of natural history data for youth-onset T2D to predict long-term outcomes. However, its aggressive nature in youth suggests that these patients will likely have a significant burden of disease related to cardiometabolic risk, comorbidities, and complications. In this paper, we highlight current knowledge on the pathophysiology of youth-onset T2D, diagnostic criteria, the impact of obesity on diabetes risk, comorbidities and complications, and current treatments.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.008
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0040.005
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.234
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes3
Has abstractyes

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