Spectral Analysis of Local Field Potentials in a Patient with Essential Tremor Treated with Deep Brain Stimulation in the Ventral Intermediate Nucleus of the Thalamus
Bibliographic record
Abstract
Introduction: Deep Brain Stimulation (DBS) of the ventral intermediate nucleus (VIM) of the thalamus is an established therapy for medically refractory essential tremor. Since 2014, 18 patients have undergone bilateral VIM DBS at our center in San Vicente Fundacion Rionegro Colombia. The recent availability of sensing devices such as the Percept RC has enabled direct analysis of local field potentials (LFPs) in vivo. We are presenting the characterization of the spectral dynamics of thalamic LFPs in our last patient with essential tremor implanted with the Percept RC system, comparing stimulation OFF and ON states across motor tasks.Method: A 72-year-old male with familial essential tremor underwent bilateral VIM DBS with a Percept RC neurostimulator. LFPs were recorded during three motor tasks: passive listening (15–45s), tapping with auditory cue (50–87s), and self-paced tapping (88–120s). Power spectral density (PSD) was computed using Welch’s method. Band-specific power was extracted for delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–13 Hz), beta (13–30 Hz), and gamma (30–100 Hz) bands. Peak frequency was also identified.Results: Resultados: Results: DBS ON induced distinct spectral changes. In passive listening, peak frequency shifted from 10.01 Hz to 23.19 Hz, with reduced alpha and beta power. During tapping with cue, low-frequency bands remained dominant, with slight increases in delta and theta. In self-paced tapping, peak frequency dropped from 21.73 Hz to 3.17 Hz, with increased delta and theta power and reduced alpha and beta activity. These findings suggest DBS modulates thalamocortical rhythms differently across motor states.Discusión: The spectral analysis may reveals that DBS stimulation induces significant modulation of thalamocortical activity. In passive listening, stimulation shifts the dominant frequency toward higher beta ranges while suppressing overall band power, suggesting a state of cortical desynchronization. During motor tasks, particularly self-paced tapping, DBS appears to reduce high-frequency activity and enhance low-frequency bands, possibly reflecting altered motor planning and execution. These observations may support the role of DBS in reshaping neural oscillatory dynamics and may support future strategies for optimizing stimulation parameters in essential tremor therapy.Conclusions: The observations on this case could show the feasibility of LFP spectral analysis using Percept RC in essential tremor. DBS alters oscillatory dynamics in a task-dependent manner, supporting its role in motor circuit regulation. These insights may inform future strategies for adaptive DBS and biomarker development.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".