Endovascular light-activated ablation to downstage locally advanced pancreatic cancers touching major blood vessels to assess feasibility for surgical excision
Bibliographic record
Abstract
Significance Many pancreatic cancers present with the tumour apparently adherent to major blood vessels, hindering surgery. Anecdotal reports of cancers like this treated with interstitial, image guided, percutaneous photodynamic therapy show that cancers may shrink, revealing a resection plane between tumour and blood vessel, making surgical resection feasible with an improved prognosis. Approach In a new approach using endovascular light-activated ablation, 7 normal pigs were photosensitised with Verteporfin and light delivered into a major vessel to induce necrosis in the adjacent pancreas and assess effects on the vessel wall. Results 48h after light-activation, necrosis up to 15mm deep was achieved in normal pancreas adjacent to the blood vessel. The vessel showed endothelial sloughing and inflammatory changes that previous studies had shown heal safely without threat to its mechanical integrity. Conclusions Endovascular light-activated ablation may have a role in making more locally advanced pancreatic cancers suitable for surgery.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".