Do type III interferons play a role in bronchopulmonary dysplasia? 4248
Bibliographic record
Abstract
Abstract Description Bronchopulmonary Dysplasia (BPD) is the most common complication associated with prematurity. It is characterized by an arrest of lung development due to inflammatory responses induced by oxidative stress caused primarily by mechanical ventilation and oxygen supplementation. However, the mechanisms linking oxidative stress and pulmonary inflammation remain poorly understood. Recent studies have shown that type I and III interferons (IFN-I and IFN-III) disrupt lung epithelial barrier and repair process during viral infection. However, the role of IFN-III in BPD is still unknown. In this study, we aimed to assess the effects of hyperoxia on IFN-I/III production and its effects on alveolar epithelial cell (AECs) functions. For this, we used in vivo (mouse) and in vitro (AECs cell line) models of hyperoxia (>95% O2) compared to normoxia (21% O2). We found that while hyperoxia had no effects on IFN-I levels, we observed a significant increase in IFN-III production by AECs. We also found that hyperoxia reduced AECs proliferation even after return to normoxia, a feature of cellular senescence. We envision that blocking IFN-III or its receptor will reverse this phenotype. Thus, our results provide new insights into a potential novel therapeutic target for BPD. Topic Categories Immune Response Regulation: Cellular Mechanisms (IRC)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".