Understanding patient, caregiver, and prescriber preferences for an antipsychotic regimen administered once every 2 months for schizophrenia or bipolar I disorder: a qualitative interview study in North America
Bibliographic record
Abstract
OBJECTIVE: This qualitative interview study explored the preferences of people living with schizophrenia or bipolar I disorder (BP-I), caregivers, and prescribers regarding the features of long-acting injectable (LAI) antipsychotics, as well as factors influencing preferences for a hypothetical LAI administered once every 2 months. METHODS: Trained moderators conducted online video interviews with stable adult patients with schizophrenia or BP-I receiving a once-monthly LAI, caregivers, and prescribers in the United States and Canada. The interview transcripts were analyzed for themes. RESULTS: Twelve patients, five caregivers, and five prescribers were included in the schizophrenia and BP-I samples. For patients and caregivers, an ideal treatment was efficacious, administered less often than a once-monthly LAI, and had minimal or no side-effects. Important LAI features included staying on the same medication, choice of injection site, and dosing frequency. Patients and caregivers viewed a once-every-2-months LAI positively, due to fewer appointments and reduced injection impact, but noted concerns about its effectiveness and potential side-effects. When prescribing LAIs, prescribers considered patient- and treatment-related factors, access, and control. The potential for greater patient freedom and stability with a once-every-2-months LAI was noted, but a loss of dosing control was a concern. Several differences between schizophrenia and BP-I samples were identified, including the level of patient/caregiver involvement in treatment decisions and unique treatment goals. CONCLUSIONS: People living with schizophrenia or BP-I, caregivers, and prescribers in the United States and Canada generally had favorable views of LAIs administered once every 2 months. Quantitative follow-up research that extends these findings is warranted.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.020 | 0.026 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.012 | 0.009 |
| Scholarly communication | 0.004 | 0.005 |
| Open science | 0.002 | 0.006 |
| Research integrity | 0.002 | 0.004 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".