Sarcopenic obesity prevalence and clinical implications in patients with advanced knee osteoarthritis and class II-III obesity
Bibliographic record
Abstract
OBJECTIVE: , comparing various established diagnostic criteria. METHODS: We conducted a cross-sectional analysis of participants at baseline from the POMELO [Prevention of MusclE Loss in Osteoarthritis] pilot randomized clinical trial. The diagnosis of SO was based on published criteria, identifying the co-presence of low muscle function, low muscle mass, and high fat mass. Assessments included maximal handgrip strength (absolute and relative to body size), chair sit-to-stands, muscle [appendicular lean soft tissue] and fat mass measured by DXA, health-related quality of life by Euroqol EQ-5D, and physical function by 6-min walk (6MWT) and Western Ontario and McMaster Osteoarthritis Index (WOMAC). RESULTS: ), 28 % had criteria for SO (95%CI 15.5-40.4). Individuals with SO had shorter 6MWT distance, -78.6 m (p = 0.012), worse WOMAC function score, 7.2 (p = 0.046), and lower EQ-5D visual analog score, -14.7 (p = 0.016), compared to those without SO. CONCLUSION: SO was present in 28 % (95%CI 15.5-40.4) of our sample with knee OA, with clinically unfavourable implications on measured and self-reported physical function and quality of life. Identification of SO may better stratify patients and enable personalized support to preserve muscle mass and function prior to weight loss or arthroplasty considerations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".