In Vivo Quantification of White Matter Pathways in the Human Hippocampus
Bibliographic record
Abstract
The hippocampus is a key structure in cognition. Although much research has focused on defining the functions of its anatomically distinct subfields, the communication among these subfields within the hippocampal circuit, supported by white matter pathways, is theoretically key to emergent cognitive function. Yet, hippocampal white matter connections in humans have not been fully explored in vivo. By leveraging diffusion-weighted imaging and a large healthy sample (N = 653), we developed a processing pipeline for in vivo quantification of human hippocampal pathways. We provided evidence for monosynaptic and trisynaptic pathway-related connections in humans, supporting the described hippocampal circuit in ex vivo and animal studies. In addition to hemispheric and sex differences, the individual variability in hippocampal pathways was linked to cognitive abilities. Thus, in vivo characterization of human hippocampal pathways highlights the individual differences within these structures and paves the way for their implications in cognition, aging, and diseases.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".