Prevalence of anxiety and depression following small subcortical ischemic stroke and their association with MRI-defined brain damage: The DHU-LAC cohort study
Bibliographic record
Abstract
• We found a high prevalence of anxiety and depression in a clinically homogeneous cohort of patients with minor stroke. • Lower levels of anxiety and depression—even among patients who had achieved near-complete recovery—were still associated with better cognitive outcomes and higher perceived quality of life. • Despite the homogeneity of this cohort, no imaging markers were identified as significant predictors of elevated anxiety or depression six months after stroke. : Data on imaging predictors of anxiety and depression remain limited in patients with minor stroke. We aimed to evaluate their prevalence six months after minor stroke and to determine whether MRI markers can help identify patients at increased risk. : DHU-LAC is an ongoing multicentre prospective French study including patients with minor ischaemic stroke likely due to cerebral small vessel disease. Anxiety and depression were assessed at baseline and 6 months using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D; scores≥8 indicating mild, ≥11 moderate symptoms). Disability was measured with the modified Rankin Scale (mRS), global cognition with the Montreal Cognitive Assessment (MOCA), and quality of life with the EQ-5D. Brain damage on MRI was assessed via the CSVD score. Predictors of HADS-A and HADS-D were explored using linear mixed-effects models. : Among 163 patients (mean age 63±11 years; 28% women), residual disability was minimal at 6 months (median mRS [interquartile range]: 1 [0.5–1.5]). At that time, 40% of patients showed mild to moderate anxiety scores, and 19% mild to moderate depression scores. In multivariable models, lower anxiety and depression scores were associated with better EQ-5D (β=–0.045, p<0.001; β =–0.13, p=0.021 respectively) and MOCA (β=–0.058, p<0.001; β=–0.11, p=0.028) scores. No consistent clinical or imaging predictors of elevated anxiety or depression scores were identified. : Anxiety and depression are common after minor stroke despite minimal physical disability. The absence of clear imaging or clinical predictors highlights the importance of systematic psychological screening, even in patients with minor stroke.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".