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Climate Impact of Inhalers: Patient Empowerment Drives Prescription Change

2025· article· W4416635882 on OpenAlexaff
Rosemarie Vincent, Sara Elatris, Samia Benabess, Shaainthabie Karthigesu, Isabelle Pitrou, Linda Ofiara, Emily G. McDonald, Nicole Ezer

Bibliographic record

Venuenot available
Typearticle
Language
FieldMedicine
TopicInhalation and Respiratory Drug Delivery
Canadian institutionsMcGill University Health CentreMcGill University
Fundersnot available
KeywordsOddsAsthmaLogistic regressionCarbon footprintOdds ratioHealth literacy

Abstract

fetched live from OpenAlex

Studies show patients are unaware of the climate impact of metered dose inhalers (MDI) vs. dry powder inhalers (DPI) but are open to change inhalers. We aimed to assess the efficacy of empowering patients to change inhaler for environmental reasons. Stable asthmatic patients on MDI (salbutamol) were given an educational pamphlet and a pre-filled DPI (terbutaline) prescription. Primary outcome was MDI to DPI rotation at 30 days. Secondary outcomes were rotation back from DPI to MDI at 90 days and patient and provider perspectives. Odds of rotation were assessed with multivariate logistic regressions. We enrolled 54 patients (mean age 57) with a mean asthma control test [ACT] score of 20 and surveyed 7 providers. Higher health literacy correlated with better asthma control (p=0.007). Both groups had low awareness of inhalers' climate impact (94% patients, 71% providers) but valued reducing carbon footprint (70% patients, 57% providers) and ease of use (67% patients, 71% providers). 56% of patients and 43% of providers considered inhaler’s climate impact important. Fewer patients (43%) than providers (57%) attributed high importance to cost. Rate of rotation from MDI to DPI 24%, of whom 13% switched back to MDI at 90 days. Poor asthma control (ACT score < 20) increased odds of rotation from MDI to DPI (OR 7.5; 1.57-47.62 95% CI) after adjustment for covariates. Patients who felt empowered to decrease their carbon footprint were more likely to change inhalers (OR 2.4; 1.08- 6.07 95% CI). Empowering patients to initiate an MDI to DPI transition was a successful approach to reduce the climate impact of inhalers. Patients and providers value lowering climate impact, and poor asthma control doesn't hinder inhaler changes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.017
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.026

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.017
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0080.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.321
Teacher spread0.298 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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